Treatment modalities had no significant effect on long-term outcome.
At 3 and 6 years, 18% and 6% of the children, respectively, had eating problems. At 15 months of age, 74% of the children had satisfactory eating behavior, and 15% had serious difficulties. At 6 years, children's speech showed persistent rhinolalia, which was mild (47%), moderate (11%), or major (11%). For children 15 months of age, language scores were below the average, as were scores for vocabulary at 3 years for half of the patients. The 24 oldest children were enrolled in the appropriate junior high school grade at the normal age. Cognitive scores were within normal ranges and increased over time, from 90.5 at 15 months of age to 109.1 at 6 years. Results were analyzed by diagnosis, extent of respiratory and feeding disorders, and treatment modalities. Psychomotor and cognitive levels, speech, and eating behavior were assessed at 15 months of age and 3 and 6 years of age 24 of the oldest children were interviewed at age 11 or 12 years.
#Pierre robin sequence adults series#
We conducted a longitudinal prospective study analyzing the long-term developmental outcome of a consecutive series of 39 children with PRS who had an a priori good prognosis (isolated PRS or PRS associated with a Stickler syndrome) but severe neonatal disorders (respiratory and feeding difficulties). Pierre Robin sequence (PRS) is a congenital condition with a heterogeneous and imprecise developmental prognosis.
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